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|Medication:||Generic Lasix (Furosemide)||Generic Lasix (Furosemide)|
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Lasix is used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid (water) from the body. These conditions include congestive heart failure, cirrhosis of the liver, and kidney disease.
Manufacturer : Aventis Pharma.
Content : Furosemide.
Cardiac, hepatic and renal oedema (in the presence of nephrotic syndrome, treatment of the basic disorder is the prime concern). Oedema due to burns. Mild to moderate hypertension.
Oedema due to cardiac and hepatic disease (ascites). Oedema due to renal disease (in the nephrotic syndrome, therapy of underlying diseases has precedence). Acute cardiac insufficiency, especially in pulmonary oedema (administration in conjunction with other therapeutic measures). Reduced urinary output due to gestoses (after restoring the fluid volume to normal). Supportive measures in brain oedema. Oedema due to burns. Hypertensive crisis (in addition to other antihypertensive measures). To support forced diuresis in poisoning.
Unless otherwise prescribed by the doctor, the following guidelines apply: In adults, treatment usually begin with ?-1-2 tabs daily; maintenance dose: ?-1 tab daily.
In infants and children, furosemide is usually administered orally. Dosage Recommendation: 2 mg furosemide/kg body weight up to a maximum of 40 mg/day.
Unless otherwise prescribed by the physician, the initial dose for adults and adolescents of ?15 years is 20-40 mg Lasix (1-2 amps) IV or IM.
If after a single dose of 20-40 mg Lasix (1-2 amps), the diuretic effect is not satisfactory, the dose may be stepwise increased at 2-hourly intervals by 20 mg (1 amp) each time, until satisfactory diuresis is obtained. The individual dose thus established should then be given once or twice daily.
Acute Pulmonary Oedema: An initial dose of 40 mg Lasix (2 amps) is administered IV. If the patient’s condition requires it, a further dose of 20-40 mg Lasix (1-2 amps) is injected after 20 min.
Forced Diuresis: 20-40 mg Lasix (1-2 amps) is given in addition to infusion of electrolyte solution.
Further treatment depends on the elimination of urine and must include substitution of the fluid and electrolyte losses.
In poisoning with acid or basic substances, the elimination rate can be further increased by alkalisation or acidification, respectively, of the urine.
Infants and Children <15 years: Parenteral administration (if necessary, continuous drip infusion) is indicated only in life-threatening conditions.
Anuria, hepatic coma, hypokalaemia, hyponatraemia, hypovolaemia with or without hypotension. Hypersensitivity to furosemide or sulfonamides.
Use in pregnancy & lactation:
Furosemide should be administered during pregnancy only if strictly indicated, and then only for short periods of time.
In breastfeeding women where the use of furosemide is considered essential, it should be borne in mind that furosemide passes into the breast milk and may inhibit lactation. In such cases, the patient should stop nursing.
In individual cases, the ability to cope with road traffic or to operate machinery may be impaired, especially at the commencement of treatment or when changing over from other drugs or when alcohol is consumed during furosemide therapy.
When a cardiac glycoside is administered concurrently, it should be remembered that potassium deficiency increases the sensitivity of the myocardium to digitalis. In case of concomitant glucocorticoid medication or abuse of laxatives, the risk of increased potassium loss should be borne in mind.
Furosemide may potentiate the nephrotoxic effects of certain antibiotics (eg, aminoglycosides). Therefore, furosemide should be used with caution in patients with antibiotic-induced renal impairment.
It should be borne in mind that the ototoxicity of aminoglycoside antibiotics (eg, kanamycin, gentamicin, tobramycin) may be potentiated when furosemide is used concurrently. The hearing defects that result may be irreversible. Therefore, this drug combination should be restricted to vital indications. As the concomitant administration of cisplatin carries the risk of inducing hearing defects, the 2 drugs should not be used simultaneously.
Furosemide sometimes diminishes the potency of other drugs (eg, the effect of antidiabetics and pressor amines) or potentiates their effect (eg, in the case of salicylates, theophylline, lithium and curarimimetic muscle relaxants).
The action of other hypotensive drugs may be potentiated by furosemide. Especially in combination with ACE inhibitors, a marked fall in blood pressure may be seen.
Nonsteroidal anti-inflammatory agents (eg, indomethacin) may antagonise the action of furosemide and may cause renal failure in case of preexisting hypovolaemia.
Protect from light.
Tab 40 mg x 100’s. , Tab 40 mg x 500’s
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Lasix is a registered trademark of Aventis Pharma, Inc.